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Engineering stability, longevity, and miscibility of microtubule-based active...
This study describes the formulation and properties of active fluids that contain mixtures of microtubules, polymer solutions, microtubule motor proteins, and ATP. These fluids are isotropic materials...
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The endoplasmic reticulum chaperone BiP is a closure-accelerating cochaperone...
From the article: “The endoplasmic reticulum (ER) is the site at which secreted proteins (such as the hormone insulin) and membrane-bound proteins are folded. ATP-dependent chaperones within the ER...
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Congratulations to Debora!
Congratulations to Dr. Deborah Tenenbaum, shown here with her two Ph.D. mentors Jeff Gelles (smiling under the mask) and Jane Kondev. Debi just successfully defended her combined theory and experiment...
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Bayesian machine learning analysis of single-molecule fluorescence...
From Science at Brandeis: “Yerdos Ordabayev et al. in the Department of Biochemistry use Bayesian probabilistic programming to implement computer software “Tapqir” for analysis of colocalization...
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Congrats to Dr. Herlambang!
Warmest congratulations to Karina Herlambang, who just defended her dissertation! Karina is moving on with her Ph.D. to work as a scientist at Intellia Therapeutics.
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Single-molecule analysis of actin filament debranching by cofilin and GMF
The Arp2/3 complex is a multi-component molecular machine that nucleates branched actin filament networks at the leading edge of cells to promote protrusion and at sites of endocytosis to drive...
View Article“Be Open To A Lot of Things”: A Brandeis Alum’s Advice on the Biochemistry &...
Of related interest: the Brandeis Graduate School of Arts and Sciences published an news article on the Biochemistry and Biophysics Ph.D. Program featuring recent Gelles Lab alumna Karina Herlambang.
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Recycling of bacterial RNA polymerase by the Swi2/Snf2 ATPase RapA
Molecular recycling is essential to gene expression. In all organisms, after each RNA molecule is made, the RNA polymerase (RNAP) enzyme that made it must be reset and repositioned to make subsequent...
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The defense of Dr. Inlow!
Congratulations to Koe Inlow on the completion of her PhD as a joint student in the Gelles and Kondev labs! Koe finished her dissertation in under 5 years, has published some of the work here and...
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RNA polymerase sliding on DNA can couple the transcription of nearby...
Transcription initiation is arguably the single most important process for the regulation of gene expression in all organisms. In bacteria, it is a widely accepted dogma that regulated transcription...
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